CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells
JA Bowles, GJ Weiner - Journal of immunological methods, 2005 - Elsevier
CD16 and natural killer (NK) cells appear to play a central role in mediating the anti-tumor
effects of monoclonal antibody (mAb) therapy, yet little is known about changes in NK cells
that result from interaction of the NK cells with mAb-coated tumor cells under physiologic
conditions. We developed a system using peripheral blood mononuclear cells (PBMCs) and
either transformed B cells or breast cancer cells to assess how mAbs impact on NK cell
phenotype. Rituximab, apolizumab and trastuzumab induced modulation of CD16 and …
effects of monoclonal antibody (mAb) therapy, yet little is known about changes in NK cells
that result from interaction of the NK cells with mAb-coated tumor cells under physiologic
conditions. We developed a system using peripheral blood mononuclear cells (PBMCs) and
either transformed B cells or breast cancer cells to assess how mAbs impact on NK cell
phenotype. Rituximab, apolizumab and trastuzumab induced modulation of CD16 and …