[HTML][HTML] CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP …
P Leahy, DR Crawford, G Grossman… - Journal of Biological …, 1999 - ASBMB
Nuclear factor I (NFI) binds to a region of the phosphoenolpyruvate carboxykinase
(GTP)(PEPCK) gene promoter adjacent to the cAMP regulatory element (CRE) and inhibits
the induction of transcription from the gene promoter caused by the catalytic subunit of
protein kinase A. In vivo footprinting studies demonstrated that both the CRE and the NFI-
binding site are occupied by transcription factors, regardless of the presence of factors that
stimulate (dibutyryl cAMP or dexamethasone) or inhibit (insulin) transcription from the …
(GTP)(PEPCK) gene promoter adjacent to the cAMP regulatory element (CRE) and inhibits
the induction of transcription from the gene promoter caused by the catalytic subunit of
protein kinase A. In vivo footprinting studies demonstrated that both the CRE and the NFI-
binding site are occupied by transcription factors, regardless of the presence of factors that
stimulate (dibutyryl cAMP or dexamethasone) or inhibit (insulin) transcription from the …