Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma
MA Avila, C Berasain, L Torres, A Martin-Duce… - Journal of …, 2000 - Elsevier
Background/Aims: It has been known for at least 50 years that alterations in methionine
metabolism occur in human liver cirrhosis. However, the molecular basis of this alteration is
not completely understood. In order to gain more insight into the mechanisms behind this
condition, mRNA levels of methionine adenosyltransferase (MAT1A), glycine
methyltransferase (GNMT), methionine synthase (MS), betaine homocysteine
methyltransferase (BHMT) and cystathionine β-synthase (CBS) were examined in 26 …
metabolism occur in human liver cirrhosis. However, the molecular basis of this alteration is
not completely understood. In order to gain more insight into the mechanisms behind this
condition, mRNA levels of methionine adenosyltransferase (MAT1A), glycine
methyltransferase (GNMT), methionine synthase (MS), betaine homocysteine
methyltransferase (BHMT) and cystathionine β-synthase (CBS) were examined in 26 …