[HTML][HTML] A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease
M Yanagisawa, D Huveldt, P Kreinest… - Journal of biological …, 2008 - ASBMB
p120 catenin is a cadherin-associated protein that regulates Rho GTPases and promotes
the invasiveness of E-cadherin-deficient cancer cells. Multiple p120 isoforms are expressed
in cells via alternative splicing, and all of them are essential for HGF signaling to Rac1.
However, only full-length p120 (isoform 1) promotes invasiveness. This selective ability of
p120 isoform 1 is mediated by reduced RhoA activity, both under basal conditions and
following HGF treatment. All p120 isoforms can bind RhoA in vitro, via a central RhoA …
the invasiveness of E-cadherin-deficient cancer cells. Multiple p120 isoforms are expressed
in cells via alternative splicing, and all of them are essential for HGF signaling to Rac1.
However, only full-length p120 (isoform 1) promotes invasiveness. This selective ability of
p120 isoform 1 is mediated by reduced RhoA activity, both under basal conditions and
following HGF treatment. All p120 isoforms can bind RhoA in vitro, via a central RhoA …