[HTML][HTML] Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation
VC Arantes, MAB Reis, AR Leite, EM Carneiro… - The Journal of …, 2002 - Elsevier
Intrauterine and early postnatal malnutrition has profound consequences on fetal and
postnatal development in both humans and animals. In addition, low birth weight has been
reported to be associated with impaired insulin secretion, insulin resistance and diminished
area of pancreatic islets. Because the transcription factor pancreatic and duodenal
homeobox 1 (PDX-1) is important for the maintenance of B-cell physiology, PDX-1
expression and islet area were assessed in neonatal rats of dams fed low (6%) or normal …
postnatal development in both humans and animals. In addition, low birth weight has been
reported to be associated with impaired insulin secretion, insulin resistance and diminished
area of pancreatic islets. Because the transcription factor pancreatic and duodenal
homeobox 1 (PDX-1) is important for the maintenance of B-cell physiology, PDX-1
expression and islet area were assessed in neonatal rats of dams fed low (6%) or normal …