Binding of mutagenic heterocyclic amines by intestinal and lactic acid bacteria
K Orrhage, E Sillerström, JÅ Gustafsson… - Mutation Research …, 1994 - Elsevier
Lactic acid bacteria have been reported to have antimutagenic/anticarcinogenic properties
in vitro and in vivo. One possible mechanism for this effect involves a physical binding of the
mutagenic compounds to the bacteria. The purpose of the present investigation was to study
the binding capacity of eight human intestinal or lactac acid bacterial strains of mutagenic
heterocyclic amines formed during cooking of protein-rich food. Binding of the mutagens Trp-
P-2, PhIP, IQ and MeIQx by the bacterial strains was analyzed by HPLC. There were only …
in vitro and in vivo. One possible mechanism for this effect involves a physical binding of the
mutagenic compounds to the bacteria. The purpose of the present investigation was to study
the binding capacity of eight human intestinal or lactac acid bacterial strains of mutagenic
heterocyclic amines formed during cooking of protein-rich food. Binding of the mutagens Trp-
P-2, PhIP, IQ and MeIQx by the bacterial strains was analyzed by HPLC. There were only …