Use of gastric acid–suppressive agents and the risk of community-acquired Clostridium difficile–associated disease
ContextRecent reports suggest an increasing occurrence and severity of Clostridium difficile–
associated disease. We assessed whether the use of gastric acid–suppressive agents is
associated with an increased risk in the community. ObjectiveTo determine whether the use
of gastric acid–suppressive agents increases the risk of C difficile–associated disease in a
community population. Design, Setting, and PatientsWe conducted 2 population-based case-
control studies using the United Kingdom General Practice Research Database (GPRD). In …
associated disease. We assessed whether the use of gastric acid–suppressive agents is
associated with an increased risk in the community. ObjectiveTo determine whether the use
of gastric acid–suppressive agents increases the risk of C difficile–associated disease in a
community population. Design, Setting, and PatientsWe conducted 2 population-based case-
control studies using the United Kingdom General Practice Research Database (GPRD). In …