[HTML][HTML] Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation
CH Widberg, NJ Bryant, M Girotti, S Rea… - Journal of Biological …, 2003 - ASBMB
The Sec1p-like/Munc18 (SM) protein Munc18a binds to the neuronal t-SNARE Syntaxin1A
and inhibits SNARE complex assembly. Tomosyn, a cytosolic Syntaxin1A-binding protein, is
thought to regulate the interaction between Syntaxin1A and Munc18a, thus acting as a
positive regulator of SNARE assembly. In the present study we have investigated the
interaction between b-Tomosyn and the adipocyte SNARE complex involving
Syntaxin4/SNAP23/VAMP-2 and the SM protein Munc18c, in vitro, and the potential …
and inhibits SNARE complex assembly. Tomosyn, a cytosolic Syntaxin1A-binding protein, is
thought to regulate the interaction between Syntaxin1A and Munc18a, thus acting as a
positive regulator of SNARE assembly. In the present study we have investigated the
interaction between b-Tomosyn and the adipocyte SNARE complex involving
Syntaxin4/SNAP23/VAMP-2 and the SM protein Munc18c, in vitro, and the potential …