[HTML][HTML] Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation
FJ Dufort, MR Gumina, NL Ta, Y Tao, SA Heyse… - Journal of Biological …, 2014 - ASBMB
Bacterially derived lipopolysaccharide (LPS) stimulates naive B lymphocytes to differentiate
into immunoglobulin (Ig)-secreting plasma cells. Differentiation of B lymphocytes is
characterized by a proliferative phase followed by expansion of the intracellular membrane
secretory network to support Ig production. A key question in lymphocyte biology is how
naive B cells reprogram metabolism to support de novo lipogenesis necessary for
proliferation and expansion of the endomembrane network in response to LPS. We report …
into immunoglobulin (Ig)-secreting plasma cells. Differentiation of B lymphocytes is
characterized by a proliferative phase followed by expansion of the intracellular membrane
secretory network to support Ig production. A key question in lymphocyte biology is how
naive B cells reprogram metabolism to support de novo lipogenesis necessary for
proliferation and expansion of the endomembrane network in response to LPS. We report …