[PDF][PDF] The SirT3 divining rod points to oxidative stress
EL Bell, L Guarente - Molecular cell, 2011 - cell.com
EL Bell, L Guarente
Molecular cell, 2011•cell.comSirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin
research has focused on SirT1, which deacetylates transcription factors and cofactors in the
nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates
metabolism and oxidative stress. This review focuses on new data linking SirT3 to
management of reactive oxygen species from mitochondria, which may have profound
implications for aging and late-onset diseases.
research has focused on SirT1, which deacetylates transcription factors and cofactors in the
nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates
metabolism and oxidative stress. This review focuses on new data linking SirT3 to
management of reactive oxygen species from mitochondria, which may have profound
implications for aging and late-onset diseases.
Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative stress. This review focuses on new data linking SirT3 to management of reactive oxygen species from mitochondria, which may have profound implications for aging and late-onset diseases.
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