An inauspicious start to 2009, unfortunately. This issue may seem a little thinner than others we’ve recently published, as 4 articles that were previously accepted and scheduled for publication in this issue will not appear. We continue to screen all figures from accepted manuscripts, and we continue to find irregularities. In several cases, the alterations in the figures led to the discovery of some fundamental problems with the data. Many of the papers suffered from the same problems, and this led us to consider whether it was time to revisit some experimental basics.