[PDF][PDF] Genetic and epigenetic variations in iPSCs: potential causes and implications for application

G Liang, Y Zhang - Cell stem cell, 2013 - cell.com
Cell stem cell, 2013cell.com
The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has
revolutionized the field of regenerative medicine. However, recent studies on the genetic
and epigenetic variations in iPSCs have raised concerns that these variations may
compromise the utility of iPSCs. In this Perspective, we review the current understanding of
genetic and epigenetic variations in iPSCs, trace their causes, discuss the implications of
these variations for iPSC applications, and propose approaches to cope with these …
The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine. However, recent studies on the genetic and epigenetic variations in iPSCs have raised concerns that these variations may compromise the utility of iPSCs. In this Perspective, we review the current understanding of genetic and epigenetic variations in iPSCs, trace their causes, discuss the implications of these variations for iPSC applications, and propose approaches to cope with these variations.
cell.com