[HTML][HTML] Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors

X Pan, O Ohneda, K Ohneda, F Lindeboom… - Journal of Biological …, 2005 - ASBMB
Transcription factor GATA-1 plays an important role in gene regulation during the
development of erythroid cells. Several reports suggest that GATA-1 plays multiple roles in
survival, proliferation, and differentiation of erythroid cells. However, little is known about the
relationship between the level of GATA-1 expression and its nature of multifunction to affect
erythroid cell fate. To address this issue, we developed in vitro embryonic stem (ES) culture
system by using OP9 stromal cells (OP9/ES cell co-culture system), and cultured the mutant …