Systemic and local high mobility group box 1 concentrations during severe infection

MAD van Zoelen, PF Laterre, SQ van Veen… - Critical care …, 2007 - journals.lww.com
Objective: High mobility group box 1 (HMGB1) has been implicated as a late mediator in
sepsis. We here sought to determine the extent of HMGB1 release in patients with sepsis
stratified to the three most common infectious sources and to determine HMGB1
concentrations at the site of infection during peritonitis or pneumonia. Design: Observational
studies in patients and healthy humans challenged with lipopolysaccharide. Setting: Three
intensive care units and one clinical research unit. Patients and Subjects: Three patient …