Lysyl oxidase (LOX) is a copper-and lysyl-tyrosyl cofactor containing amine oxidase that has
been known to play a critical role in the catalysis of lysine-derived crosslinks in extracellular
matrix (ECM) proteins in the dermis. Changes in the composition and crosslinked state of the
ECM and alterations in LOX synthesis and activity are known to be associated with aging
and a range of acquired and heritable skin disorders. It has been assumed until recently that
the LOX-related changes in the skin are mediated through the catalytic activity of LOX …