[HTML][HTML] Lysyl Oxidase Binds Transforming Growth Factor-; and Regulates Its Signaling via Amine Oxidase Activity
P Atsawasuwan, Y Mochida, M Katafuchi… - Journal of biological …, 2008 - ASBMB
Lysyl oxidase (LOX), an amine oxidase critical for the initiation of collagen and elastin cross-
linking, has recently been shown to regulate cellular activities possibly by modulating the
functions of growth factors. In this study, we investigated the interaction between LOX and
transforming growth factor-; 1 (TGF-; 1), a potent growth factor abundant in bone, the effect of
LOX on TGF-; 1 signaling, and its potential mechanism. The specific binding between
mature LOX and mature TGF-; 1 was demonstrated by immunoprecipitation and glutathione …
linking, has recently been shown to regulate cellular activities possibly by modulating the
functions of growth factors. In this study, we investigated the interaction between LOX and
transforming growth factor-; 1 (TGF-; 1), a potent growth factor abundant in bone, the effect of
LOX on TGF-; 1 signaling, and its potential mechanism. The specific binding between
mature LOX and mature TGF-; 1 was demonstrated by immunoprecipitation and glutathione …