EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

M Lazarus, K Yoshida, R Coppari, CE Bass… - Nature …, 2007 - nature.com
M Lazarus, K Yoshida, R Coppari, CE Bass, T Mochizuki, BB Lowell, CB Saper
Nature neuroscience, 2007nature.com
Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to
require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts
to produce fever have not been definitively established. Here we report that selective genetic
deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the
fever response. These observations demonstrate that the EP3R-bearing neurons in the
median preoptic nucleus are required for fever responses.
Abstract
Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.
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