High expression of Musashi-2 indicates poor prognosis in adult B-cell acute lymphoblastic leukemia
Q Mu, Y Wang, B Chen, W Qian, H Meng, H Tong… - Leukemia research, 2013 - Elsevier
Musashi-2 (MSI2) expression of 116 adult B-cells acute lymphoblastic leukemia (B-ALL)
patients was measured by real-time PCR. Kaplan–Meier analysis showed that patients with
high MSI2 expression had inferior overall survival (OS)(P= 0.004), event free survival
(EFS)(P= 0.001) and relapse free survival (RFS)(P= 0.018) in BCR-ABL-negative B-ALL.
Multivariate models revealed that, besides WBC more than 30× 109/L and IK6 variant of
IKZF1, high MSI2 expression was also an independent prognostic factor for adult BCR-ABL …
patients was measured by real-time PCR. Kaplan–Meier analysis showed that patients with
high MSI2 expression had inferior overall survival (OS)(P= 0.004), event free survival
(EFS)(P= 0.001) and relapse free survival (RFS)(P= 0.018) in BCR-ABL-negative B-ALL.
Multivariate models revealed that, besides WBC more than 30× 109/L and IK6 variant of
IKZF1, high MSI2 expression was also an independent prognostic factor for adult BCR-ABL …