Physiologic stress‐mediated signaling in the endothelium

CA Reinhart‐King, K Fujiwara, BC Berk - Methods in enzymology, 2008 - Elsevier
Although the vasculature was once thought to be a passive conduit for blood, it is now
known that the endothelium is responsible for healthy vascular homeostasis and the
progression of many cardiovascular‐related diseases. Because the endothelium lines blood
vessels, it is subjected to the mechanical forces due to of blood flow. It is now well
established that endothelial cells transduce these mechanical signals into chemical signals
that are evident in the mechanoregulation of a number of signal transduction pathways and …