[HTML][HTML] RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility
J Yu, D Zhang, J Liu, J Li, Y Yu, XR Wu… - Journal of Biological …, 2012 - ASBMB
The Rho GDP dissociation inhibitor (RhoGDI) can bind to small GTPases and keep them in
a biologically inactive state in cytoplasm, through which it affects actin polymerization and
cell motility. However, mechanisms underlying how RhoGDI regulates Rho GTPase complex
formation/membrane extraction/GTPase dissociation remain largely unexplored. Our
previous studies reported that X-linked inhibitor of apoptosis protein (XIAP) interacted with
RhoGDI via its RING domain and negatively modulated RhoGDI SUMOylation and HCT116 …
a biologically inactive state in cytoplasm, through which it affects actin polymerization and
cell motility. However, mechanisms underlying how RhoGDI regulates Rho GTPase complex
formation/membrane extraction/GTPase dissociation remain largely unexplored. Our
previous studies reported that X-linked inhibitor of apoptosis protein (XIAP) interacted with
RhoGDI via its RING domain and negatively modulated RhoGDI SUMOylation and HCT116 …