Molecular mechanisms that are responsible for the development of the renal collecting duct
system during embryogenesis are still poorly understood. A mouse cDNA encoding a zinc
finger protein, called Klf6, which is a member of the Kru [Combining Diaeresis] ppel-like
family of transcription factors, has been cloned. Northern blot analyses showed that Klf6 was
already expressed in 11.5-d postconception mouse embryos and that its expression
persisted after birth. They also disclosed that Klf6 had a restricted pattern of expression. In …