[HTML][HTML] NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary …
NF-E2-related factor-2 (Nrf2) regulates the gene expression of phase II detoxification
enzymes and antioxidant proteins through an enhancer sequence referred to as the
antioxidant-responsive element (ARE). In this study, we demonstrate that Nrf2 protects
neurons in mixed primary neuronal cultures containing both astrocytes (∼ 10%) and
neurons (∼ 90%) through coordinate up-regulation of ARE-driven genes. Nrf2-/-neurons in
this mixed culture system were more sensitive to mitochondrial toxin (1-methyl-4-phenyl-1, 2 …
enzymes and antioxidant proteins through an enhancer sequence referred to as the
antioxidant-responsive element (ARE). In this study, we demonstrate that Nrf2 protects
neurons in mixed primary neuronal cultures containing both astrocytes (∼ 10%) and
neurons (∼ 90%) through coordinate up-regulation of ARE-driven genes. Nrf2-/-neurons in
this mixed culture system were more sensitive to mitochondrial toxin (1-methyl-4-phenyl-1, 2 …