The role of oxidative stress in the pathogenesis of age-related macular degeneration

S Beatty, HH Koh, M Phil, D Henson, M Boulton - Survey of ophthalmology, 2000 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blind registration in the
developed world, and yet its pathogenesis remains poorly understood. Oxidative stress,
which refers to cellular damage caused by reactive oxygen intermediates (ROI), has been
implicated in many disease processes, especially age-related disorders. ROIs include free
radicals, hydrogen peroxide, and singlet oxygen, and they are often the byproducts of
oxygen metabolism. The retina is particularly susceptible to oxidative stress because of its …