[PDF][PDF] Intravitreous injection of PLGA microspheres encapsulating GDNF promotes the survival of photoreceptors in the rd1/rd1 mouse
C Andrieu-Soler, A Aubert-Pouëssel, M Doat, S Picaud… - Mol Vis, 2005 - molvis.org
C Andrieu-Soler, A Aubert-Pouëssel, M Doat, S Picaud, M Halhal, M Simonutti…
Mol Vis, 2005•molvis.orgv11a120-andrieu-soler pgmkr Page 1 Molecular Vision 2005; 11:1002-11 <http://www.molvis.org/molvis/v11/a120/>
Received 11 February 2005 | Accepted 13 June 2005 | Published 17 November 2005 The
use of exogenous growth factors to delay photoreceptors death is gaining momentum as a
neuroprotection strategy. LaVail and colleagues explored the potential of direct intravitreous
injection of fibroblast growth factor 2 (FGF2), ciliary derived neurotrophic factor (CNTF), and
brain derived neurotrophic factor (BDNF) to slow retinal degeneration in animal models [1-3] …
Received 11 February 2005 | Accepted 13 June 2005 | Published 17 November 2005 The
use of exogenous growth factors to delay photoreceptors death is gaining momentum as a
neuroprotection strategy. LaVail and colleagues explored the potential of direct intravitreous
injection of fibroblast growth factor 2 (FGF2), ciliary derived neurotrophic factor (CNTF), and
brain derived neurotrophic factor (BDNF) to slow retinal degeneration in animal models [1-3] …
METHODS
Microsphere formulation: Microspheres were prepared using a water/organic phase/water (w/o/w) emulsion solvent extrac-
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