[HTML][HTML] Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

KA Knoop, KG McDonald, S McCrate, JR McDole… - Mucosal …, 2015 - Elsevier
The delivery of luminal substances across the intestinal epithelium to the immune system is
a critical event in immune surveillance, resulting in tolerance to dietary antigens and
immunity to pathogens. How this process is regulated is largely unknown. Recently goblet
cell-associated antigen passages (GAPs) were identified as a pathway delivering luminal
antigens to underlying lamina propria (LP) dendritic cells in the steady state. Here, we
demonstrate that goblet cells (GCs) form GAPs in response to acetylcholine (ACh) acting on …