FOXP3+ regulatory T cells in the human immune system

S Sakaguchi, M Miyara, CM Costantino… - Nature Reviews …, 2010 - nature.com
S Sakaguchi, M Miyara, CM Costantino, DA Hafler
Nature Reviews Immunology, 2010nature.com
Abstract Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells are potent mediators of
dominant self tolerance in the periphery. But confusion as to the identity, stability and
suppressive function of human TReg cells has, to date, impeded the general therapeutic use
of these cells. Recent studies have suggested that human TReg cells are functionally and
phenotypically diverse. Here we discuss recent findings regarding human TReg cells,
including the ontogeny and development of TReg cell subsets that have naive or memory …
Abstract
Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells are potent mediators of dominant self tolerance in the periphery. But confusion as to the identity, stability and suppressive function of human TReg cells has, to date, impeded the general therapeutic use of these cells. Recent studies have suggested that human TReg cells are functionally and phenotypically diverse. Here we discuss recent findings regarding human TReg cells, including the ontogeny and development of TReg cell subsets that have naive or memory phenotypes, the unique mechanisms of suppression mediated by TReg cell subsets and factors that regulate TReg cell lineage commitment. We discuss future studies that are needed for the successful therapeutic use of human TReg cells.
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