[HTML][HTML] Retinopathy in mice induced by disrupted all-trans-retinal clearance

A Maeda, T Maeda, M Golczak, K Palczewski - Journal of Biological …, 2008 - ASBMB
The visual (retinoid) cycle is a fundamental metabolic process in vertebrate retina
responsible for production of 11-cis-retinal, the chromophore of rhodopsin and cone
pigments. 11-cis-Retinal is bound to opsins, forming visual pigments, and when the resulting
visual chromophore 11-cis-retinylidene is photoisomerized to all-trans-retinylidene, all-trans-
retinal is released from these receptors. Toxic byproducts of the visual cycle formed from all-
trans-retinal often are associated with lipofuscin deposits in the retinal pigmented epithelium …