Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells
CC Chen, V Llado, K Eurich, HT Tran, E Mizoguchi - Clinical immunology, 2011 - Elsevier
Host–microbial interactions play a key role during the development of colitis. We have
previously shown that chinase 3-like 1 (CHI3L1) is an inducible molecule overexpressed in
colonic epithelial cells (CECs) under inflammatory conditions. In this study, we found that
chitin-binding motif (CBM) of CHI3L1 is specifically associated with the CHI3L1-mediated
activation of the Akt-signaling in CEC by transfecting the CBM-mutant CHI3L1 vectors in
SW480 CECs. Downstream, CHI3L1 enhanced the secretion of IL-8 and TNFα in a dose …
previously shown that chinase 3-like 1 (CHI3L1) is an inducible molecule overexpressed in
colonic epithelial cells (CECs) under inflammatory conditions. In this study, we found that
chitin-binding motif (CBM) of CHI3L1 is specifically associated with the CHI3L1-mediated
activation of the Akt-signaling in CEC by transfecting the CBM-mutant CHI3L1 vectors in
SW480 CECs. Downstream, CHI3L1 enhanced the secretion of IL-8 and TNFα in a dose …