Isl1 is required for multiple aspects of motor neuron development

X Liang, MR Song, ZG Xu, GM Lanuza, Y Liu… - Molecular and Cellular …, 2011 - Elsevier
The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and
plays essential roles during embryogenesis. Isl1 is required for the survival and specification
of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the
role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we
generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed
essential roles of Isl1 in multiple aspects of motor neuron development, including motor …