[HTML][HTML] Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during …

C Zhang, Y Li, Y Wu, L Wang, X Wang, J Du - Journal of Biological …, 2013 - ASBMB
Inflammation and microenvironment play a crucial role in muscle regeneration. IL
(interleukin)-6, as a multifunctional cytokine is involved in the processes. However, the
causative effect of IL-6 in muscle regeneration remains unclear. In a mouse model of
cardiotoxin-induced muscle injury/regeneration, infiltrated monocytes/macrophages produce
a high level of IL-6 started on 1 day (24 h) after injury. In IL-6 knock-out (−/−) mice, the
muscle regeneration procedure was impaired along with decreased myogenic …