Well-differentiated and dedifferentiated liposarcomas
JM Coindre, F Pédeutour, A Aurias - Virchows Archiv, 2010 - Springer
JM Coindre, F Pédeutour, A Aurias
Virchows Archiv, 2010•SpringerAtypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and
dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality
characterized by a simple genomic profile with a 12q14–15 amplification involving MDM2
gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology,
general clinical and imaging features, histopathology, new diagnostic tools, and prognosis
of ALT-WDLPS and DDLPS.
dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality
characterized by a simple genomic profile with a 12q14–15 amplification involving MDM2
gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology,
general clinical and imaging features, histopathology, new diagnostic tools, and prognosis
of ALT-WDLPS and DDLPS.
Abstract
Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14–15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.
Springer