[HTML][HTML] Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in …
X Hu, K Bardhan, AV Paschall, D Yang… - Journal of Biological …, 2013 - ASBMB
Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that
accumulate in response to tumor progression. Compelling data from mouse models and
human cancer patients showed that tumor-induced inflammatory mediators induce MDSC
differentiation. However, the mechanisms underlying MDSC persistence is largely unknown.
Here, we demonstrated that tumor-induced MDSCs exhibit significantly decreased
spontaneous apoptosis as compared with myeloid cells with the same phenotypes from …
accumulate in response to tumor progression. Compelling data from mouse models and
human cancer patients showed that tumor-induced inflammatory mediators induce MDSC
differentiation. However, the mechanisms underlying MDSC persistence is largely unknown.
Here, we demonstrated that tumor-induced MDSCs exhibit significantly decreased
spontaneous apoptosis as compared with myeloid cells with the same phenotypes from …