[HTML][HTML] Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
F Heindryckx, K Mertens, N Charette, B Vandeghinste… - Molecular cancer, 2010 - Springer
F Heindryckx, K Mertens, N Charette, B Vandeghinste, C Casteleyn, C Van Steenkiste…
Molecular cancer, 2010•SpringerBackground The increasing incidence of hepatocellular carcinoma in Western countries has
led to an expanding interest of scientific research in this field. Therefore, a vast need of
experimental models that mimic the natural pathogenesis of hepatocellular carcinoma
(HCC) in a short time period is present. The goal of our study was (1) to develop an efficient
mouse model for HCC research, in which tumours develop in a natural background of
fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of …
led to an expanding interest of scientific research in this field. Therefore, a vast need of
experimental models that mimic the natural pathogenesis of hepatocellular carcinoma
(HCC) in a short time period is present. The goal of our study was (1) to develop an efficient
mouse model for HCC research, in which tumours develop in a natural background of
fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of …
Background
The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC.
Methods
Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC.
Results
The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets.
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