Mouse KLF11 regulates hepatic lipid metabolism
H Zhang, Q Chen, M Yang, B Zhu, Y Cui, Y Xue… - Journal of …, 2013 - Elsevier
Background & Aims Missense mutations in human Krüppel-like factor 11 (KLF11) lead to the
development of diabetes, as a result of impaired insulin synthesis in the pancreas. However,
the role of KLF11 in peripheral tissues is largely unknown. The aim of this study is to
evaluate the role of KLF11 in the regulation of hepatic lipid homeostasis using different
mouse models. Methods Adenoviruses expressing KLF11 (Ad-KLF11) or KLF11-specific
shRNA (Ad-sh KLF11) were injected into db/db diabetic, high-fat diet-induced obese (DIO) …
development of diabetes, as a result of impaired insulin synthesis in the pancreas. However,
the role of KLF11 in peripheral tissues is largely unknown. The aim of this study is to
evaluate the role of KLF11 in the regulation of hepatic lipid homeostasis using different
mouse models. Methods Adenoviruses expressing KLF11 (Ad-KLF11) or KLF11-specific
shRNA (Ad-sh KLF11) were injected into db/db diabetic, high-fat diet-induced obese (DIO) …