[HTML][HTML] Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejection
Macrophage accumulation within an acutely rejecting allograft occurs by recruitment and
local proliferation. To determine the importance of M-CSF in driving macrophage
proliferation during acute rejection, we blocked the M-CSF receptor, c-fms, in a mouse
model of acute renal allograft rejection. C57BL/6 mouse kidneys (allografts, n= 20) or
BALB/c kidneys (isografts, n= 5) were transplanted into BALB/c mice. Anti-c-fms antibody
(AFS98) or control Ig (50 mg/kg/day, ip) was given daily to allografts from days 0–5. All mice …
local proliferation. To determine the importance of M-CSF in driving macrophage
proliferation during acute rejection, we blocked the M-CSF receptor, c-fms, in a mouse
model of acute renal allograft rejection. C57BL/6 mouse kidneys (allografts, n= 20) or
BALB/c kidneys (isografts, n= 5) were transplanted into BALB/c mice. Anti-c-fms antibody
(AFS98) or control Ig (50 mg/kg/day, ip) was given daily to allografts from days 0–5. All mice …