Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes
S Chen, FF He, H Wang, Z Fang, N Shao, XJ Tian… - Cell calcium, 2011 - Elsevier
Albumin, which is the most abundant component of urine proteins, exerts injurious effects on
renal cells in chronic kidney diseases. However, the toxicity of albumin to podocytes is not
well elucidated. Here, we show that a high concentration of albumin triggers intracellular
calcium ([Ca2+] i) increase through mechanisms involving the intracellular calcium store
release and extracellular calcium influx in conditionally immortalized podocytes. The
canonical transient receptor potential-6 (TRPC6) channel, which is associated with a subset …
renal cells in chronic kidney diseases. However, the toxicity of albumin to podocytes is not
well elucidated. Here, we show that a high concentration of albumin triggers intracellular
calcium ([Ca2+] i) increase through mechanisms involving the intracellular calcium store
release and extracellular calcium influx in conditionally immortalized podocytes. The
canonical transient receptor potential-6 (TRPC6) channel, which is associated with a subset …