Activation of NFAT signaling in podocytes causes glomerulosclerosis
Y Wang, G Jarad, P Tripathi, M Pan… - Journal of the …, 2010 - journals.lww.com
Mutant forms of TRPC6 can activate NFAT-dependent transcription in vitro via calcium influx
and activation of calcineurin. The same TRPC6 mutants can cause FSGS, but whether this
involves an NFAT-dependent mechanism is unknown. Here, we generated mice that allow
conditional induction of NFATc1. Mice with NFAT activation in nascent podocytes in utero
developed proteinuria and glomerulosclerosis postnatally, resembling FSGS. NFAT
activation in adult mice also caused progressive proteinuria and FSGS. Ultrastructural …
and activation of calcineurin. The same TRPC6 mutants can cause FSGS, but whether this
involves an NFAT-dependent mechanism is unknown. Here, we generated mice that allow
conditional induction of NFATc1. Mice with NFAT activation in nascent podocytes in utero
developed proteinuria and glomerulosclerosis postnatally, resembling FSGS. NFAT
activation in adult mice also caused progressive proteinuria and FSGS. Ultrastructural …