β2-Adrenoceptor activation attenuates endotoxin-induced acute renal failure

A Nakamura, A Imaizumi, Y Yanagawa… - Journal of the …, 2004 - journals.lww.com
Abnormalities in the β 2-adrenergic control of organ function have been implicated in the
pathogenesis of several disease states, such as septic shock. The objectives of the present
study were to define the contribution of β 2-adrenoceptors (β 2-AR) to normal renal
physiology and to investigate whether overexpression of renal β 2-AR might be potentially
beneficial in preventing progressive renal damage associated with endotoxemia. Adenoviral
transgenes containing the human β 2-AR (Adeno-β 2-AR) were constructed and delivered …