Alloreactivity and apoptosis in graft rejection and transplantation tolerance

N Zavazava, D Kabelitz - Journal of leukocyte biology, 2000 - academic.oup.com
N Zavazava, D Kabelitz
Journal of leukocyte biology, 2000academic.oup.com
Weissmann wrote as early as 1889 that higher organisms contain within themselves the
germs of death. However, the term, programmed cell death, or apoptosis as it is now known,
was defined much later. Thus, it was long recognized that damaged and old cells are
eliminated within the body, but the underlying mechanisms are only now beginning to
emerge. Apoptosis appears central to the process of negative selection of developing T-cells
in the thymus. In regard to organ transplantation, apoptosis contributes to graft rejection and …
Abstract
Weissmann wrote as early as 1889 that higher organisms contain within themselves the germs of death . However, the term, programmed cell death, or apoptosis as it is now known, was defined much later . Thus, it was long recognized that damaged and old cells are eliminated within the body, but the underlying mechanisms are only now beginning to emerge. Apoptosis appears central to the process of negative selection of developing T-cells in the thymus. In regard to organ transplantation, apoptosis contributes to graft rejection and the establishment of graft tolerance. Thus, understanding the regulatory mechanisms of apoptosis may help establish a new protocol for the induction of transplantation tolerance.
Oxford University Press