Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G− 765C polymorphism in African-Americans: The Atherosclerosis Risk in …
BACKGROUND: A hallmark feature of atherosclerosis is inflammation mediated by
prostaglandins (PGs) catalyzed by the enzyme cyclooxygenase (COX). The present study
explored whether the COX-2 G− 765C polymorphism contributes to increased incidence of
coronary heart disease (CHD) or stroke in the large prospective Atherosclerosis Risk in
Communities (ARIC) Study. METHODS: Incidences of CHD and stroke were identified
through annual follow-up and hospital and death certificate surveillance. The study included …
prostaglandins (PGs) catalyzed by the enzyme cyclooxygenase (COX). The present study
explored whether the COX-2 G− 765C polymorphism contributes to increased incidence of
coronary heart disease (CHD) or stroke in the large prospective Atherosclerosis Risk in
Communities (ARIC) Study. METHODS: Incidences of CHD and stroke were identified
through annual follow-up and hospital and death certificate surveillance. The study included …