Endocytosis and cancer
S Polo, S Pece, PP Di Fiore - Current opinion in cell biology, 2004 - Elsevier
S Polo, S Pece, PP Di Fiore
Current opinion in cell biology, 2004•ElsevierEukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and
their ligands, viruses and various extracellular soluble molecules. Endocytosis has been
regarded as a long-term mechanism of signal attenuation via receptor clearance from the
cell surface. However, additional, and quite unexpected, functions for endocytosis have
emerged, which, together with its attenuation function, project a central role for this process
in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus …
their ligands, viruses and various extracellular soluble molecules. Endocytosis has been
regarded as a long-term mechanism of signal attenuation via receptor clearance from the
cell surface. However, additional, and quite unexpected, functions for endocytosis have
emerged, which, together with its attenuation function, project a central role for this process
in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus …
Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface. However, additional, and quite unexpected, functions for endocytosis have emerged, which, together with its attenuation function, project a central role for this process in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer.
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