[HTML][HTML] Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51
RJ Craven, JC Mallory, RA Hand - Journal of biological chemistry, 2007 - ASBMB
Fungal infections arise frequently in immunocompromised patients, and sterol synthesis is a
primary pathway targeted by antifungal drugs. In particular, the P450 protein Erg11/Cyp51
catalyzes a critical step in ergosterol synthesis, and the azole class of antifungal drugs
inhibits Erg11. Dap1 is a heme-binding protein related to cytochrome b 5 that activates
Erg11, so that cells lacking Dap1 accumulate the Erg11 substrate and are hypersensitive to
Erg11 inhibitors. Heme binding by Dap1 is crucial for its function, and point mutants in its …
primary pathway targeted by antifungal drugs. In particular, the P450 protein Erg11/Cyp51
catalyzes a critical step in ergosterol synthesis, and the azole class of antifungal drugs
inhibits Erg11. Dap1 is a heme-binding protein related to cytochrome b 5 that activates
Erg11, so that cells lacking Dap1 accumulate the Erg11 substrate and are hypersensitive to
Erg11 inhibitors. Heme binding by Dap1 is crucial for its function, and point mutants in its …