Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1
JD Siliciano, RF Siliciano - Journal of Allergy and Clinical Immunology, 2014 - Elsevier
HIV-1 infection can now be readily controlled with combination antiretroviral therapy.
However, the virus persists indefinitely in a stable latent reservoir in resting CD4+ T cells.
This reservoir generally prevents cure of the infection with combination antiretroviral therapy
alone. However, several recent cases of potential HIV-1 cure have generated renewed
optimism. Here we review these cases and consider new developments in our
understanding of the latent reservoir. In addition, we consider clinical aspects of curative …
However, the virus persists indefinitely in a stable latent reservoir in resting CD4+ T cells.
This reservoir generally prevents cure of the infection with combination antiretroviral therapy
alone. However, several recent cases of potential HIV-1 cure have generated renewed
optimism. Here we review these cases and consider new developments in our
understanding of the latent reservoir. In addition, we consider clinical aspects of curative …