[HTML][HTML] Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis
Factors regulating the proliferation and apoptosis of intestinal stem cells (ISCs) remain
incompletely understood. Because ISCs exist among microbial ligands, immune receptors
such as toll-like receptor 4 (TLR4) could play a role. We now hypothesize that ISCs express
TLR4 and that the activation of TLR4 directly on the intestinal stem cells regulates their
ability to proliferate or to undergo apoptosis. Using flow cytometry and fluorescent in situ
hybridization for the intestinal stem cell marker Lgr5, we demonstrate that TLR4 is expressed …
incompletely understood. Because ISCs exist among microbial ligands, immune receptors
such as toll-like receptor 4 (TLR4) could play a role. We now hypothesize that ISCs express
TLR4 and that the activation of TLR4 directly on the intestinal stem cells regulates their
ability to proliferate or to undergo apoptosis. Using flow cytometry and fluorescent in situ
hybridization for the intestinal stem cell marker Lgr5, we demonstrate that TLR4 is expressed …