[HTML][HTML] Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis
The cellular cues that regulate the apoptosis of intestinal stem cells (ISCs) remain
incompletely understood, yet may play a role in diseases characterized by ISC loss
including necrotizing enterocolitis (NEC). Toll-like receptor-4 (TLR4) was recently found to
be expressed on ISCs, where its activation leads to ISC apoptosis through mechanisms that
remain incompletely explained. We now hypothesize that TLR4 induces endoplasmic
reticulum (ER) stress within ISCs, leading to their apoptosis in NEC pathogenesis, and that …
incompletely understood, yet may play a role in diseases characterized by ISC loss
including necrotizing enterocolitis (NEC). Toll-like receptor-4 (TLR4) was recently found to
be expressed on ISCs, where its activation leads to ISC apoptosis through mechanisms that
remain incompletely explained. We now hypothesize that TLR4 induces endoplasmic
reticulum (ER) stress within ISCs, leading to their apoptosis in NEC pathogenesis, and that …