Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis
BR Cullen, PT Lomedico, G Ju - Nature, 1984 - nature.com
BR Cullen, PT Lomedico, G Ju
Nature, 1984•nature.comAbstract The downstream (3′) long terminal repeat (LTR) of an avian retroviral provirus is
unable to act as an efficient promoter of transcription when a transcriptionally active
upstream (5′) LTR is present. This transcriptional interference may explain the observation
that only deleted proviruses have been observed inserted adjacent to c-myc in avian
leukosis virus induced lymphomas of chickens.
unable to act as an efficient promoter of transcription when a transcriptionally active
upstream (5′) LTR is present. This transcriptional interference may explain the observation
that only deleted proviruses have been observed inserted adjacent to c-myc in avian
leukosis virus induced lymphomas of chickens.
Abstract
The downstream (3′) long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5′) LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.
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