[HTML][HTML] Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the RNA polymerase II carboxyl-terminal domain and …
JH Trembley, D Hu, CA Slaughter, JM Lahti… - Journal of biological …, 2003 - ASBMB
The PITSLRE protein kinases, hereafter referred to as cyclin-dependent kinase 11 (CDK11)
due to their association with cyclin L, are part of large molecular weight protein complexes
that contain RNA polymerase II (RNAP II) as well as numerous transcription and RNA
processing factors. Data presented here demonstrate that the influence of CDK11 p110 on
transcription and splicing does not involve phosphorylation of the RNAP II carboxyl-terminal
domain by CDK11 p110. We have isolated a DRB-and heparin-sensitive protein kinase …
due to their association with cyclin L, are part of large molecular weight protein complexes
that contain RNA polymerase II (RNAP II) as well as numerous transcription and RNA
processing factors. Data presented here demonstrate that the influence of CDK11 p110 on
transcription and splicing does not involve phosphorylation of the RNAP II carboxyl-terminal
domain by CDK11 p110. We have isolated a DRB-and heparin-sensitive protein kinase …