p85β phosphoinositide 3-kinase subunit regulates tumor progression
I Cortés, J Sánchez-Ruíz, S Zuluaga… - Proceedings of the …, 2012 - National Acad Sciences
I Cortés, J Sánchez-Ruíz, S Zuluaga, V Calvanese, M Marqués, C Hernández, T Rivera…
Proceedings of the National Academy of Sciences, 2012•National Acad SciencesPIK3R2 encodes a ubiquitous regulatory subunit (p85β) of PI3K, an enzyme that generates
3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and
migration. We found that p85β expression is elevated in breast and colon carcinomas and
that its increased expression correlates with PI3K pathway activation and tumor progression.
p85β expression induced moderate PIP3 generation at the cell membrane and enhanced
cell invasion. In accordance, genetic alteration of pik3r2 expression levels modulated tumor …
3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and
migration. We found that p85β expression is elevated in breast and colon carcinomas and
that its increased expression correlates with PI3K pathway activation and tumor progression.
p85β expression induced moderate PIP3 generation at the cell membrane and enhanced
cell invasion. In accordance, genetic alteration of pik3r2 expression levels modulated tumor …
PIK3R2 encodes a ubiquitous regulatory subunit (p85β) of PI3K, an enzyme that generates 3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and migration. We found that p85β expression is elevated in breast and colon carcinomas and that its increased expression correlates with PI3K pathway activation and tumor progression. p85β expression induced moderate PIP3 generation at the cell membrane and enhanced cell invasion. In accordance, genetic alteration of pik3r2 expression levels modulated tumor progression in vivo. Increased p85β expression thus represents a cellular strategy in cancer progression.
National Acad Sciences