Pathogenetic mechanisms in thyroid follicular-cell neoplasia

T Kondo, S Ezzat, SL Asa - Nature Reviews Cancer, 2006 - nature.com
Nature Reviews Cancer, 2006nature.com
Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent
advances have improved our understanding of its pathogenesis; these include the
identification of genetic alterations that activate a common effector pathway involving the
RET–Ras–BRAF signalling cascade, and other unique chromosomal rearrangements.
Some of these have been associated with radiation exposure as a pathogenetic mechanism.
Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell …
Abstract
Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET–Ras–BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.
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