Urine podocyte mRNAs, proteinuria, and progression in human glomerular diseases

L Wickman, F Afshinnia, SQ Wang, Y Yang… - Journal of the …, 2013 - journals.lww.com
Abstract Model systems demonstrate that progression to ESRD is driven by progressive
podocyte depletion (the podocyte depletion hypothesis) and can be noninvasively
monitored through measurement of urine pellet podocyte mRNAs. To test these concepts in
humans, we analyzed urine pellet mRNAs from 358 adult and pediatric kidney clinic patients
and 291 controls (n= 1143 samples). Compared with controls, urine podocyte mRNAs
increased 79-fold (P< 0.001) in patients with biopsy-proven glomerular disease and a 50 …